Study explores lipid nanoparticles against SARS-CoV-2

Study: Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant. Image Credit: Crevis/Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers assessed the efficiency of lipid nanoparticles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant. Image Credit: Crevis/Shutterstock Messenger ribonucleic acid (mRNA) vaccines have played an instrumental role in curbing coronavirus disease … Read more

Exploring short-term effectiveness of COVID-19 booster vaccine and stable CD8+ T cell memory after three doses

Study: Short-lived booster effect and stable CD8+ T cell memory after 3rd COVID-19 vaccine dose. Image Credit: KT Stock photos/Shutterstock

Since the initial global outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, a continuous evolution of the virus has been observed. The emergence of new SARS-CoV-2 variants, which have been classified as variants of concern (VOC) and variants of interest (VOI), has reduced the efficacy … Read more

Study finds recent influenza vaccination is associated with an appreciable reduction in the risk of SARS-CoV-2 infection and COVID-19 severity

Study: Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar. Image Credit: BlurryMe/Shutterstock

Several earlier studies have indicated a favorable effect of flu shots on the risk of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as on the risk of symptomatic and severe coronavirus disease 2019 (COVID-19) after infection. A new preprint reports the effectiveness of influenza vaccination in this light. Study: Effectiveness … Read more

Messenger RNA COVID-19 vaccines induce high levels of short-lived antibodies compared to natural infection

Study: High but Short-lived anti-SARS-CoV2 neutralizing, IgM, IgA, and IgG levels among mRNA-vaccinees compared to naturally-infected participants. Image Credit: PIC SNIPE/Shutterstock

In a recent study posted to the medRxiv* pre-print server, researchers extensively investigated the dynamics of antibodies induced by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination in Qatar’s diverse population. The researchers found that the two-dose vaccine regimen with a messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine boosted antibody … Read more

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Study: Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron. ​​​​​​​Image Credit: Orpheus FX / Shutterstock

In a recent study published in the journal Vaccinesresearchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron escapes neutralizing antibodies (nAbs). Two days after it was first reported on November 24, 2021, the World Health Organization (WHO) designated SARS-CoV-2 Omicron as a variant of concern (VOC). The WHO estimated a potentially higher risk of … Read more

Study Shows Unvaccinated People Are At Increased Risk Of Infecting The Vaccinated

Study Shows Unvaccinated People Are At Increased Risk Of Infecting The Vaccinated

Unvaccinated people are at increased risk of infecting the vaccinated Getty Images A new modeling study published in the Canadian Medical Association Journal demonstrates that unvaccinated people threaten the safety of the vaccinated even when SARS-CoV-2 vaccination rates are high. Researchers used a simple compartmental model of respiratory viral disease to explore the effect of … Read more

NIH launches clinical study to evaluate an investigational preventative vaccine for Epstein-Barr virus

Booster doses provide strong protection against hospitalization and death from COVID-19

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched an early-stage clinical trial to evaluate an investigational preventative vaccine for Epstein-Barr virus (EBV). EBV is the primary cause of infectious mononucleosis and is associated with certain cancers and autoimmune diseases. The Phase 1 study, which will … Read more

Evaluating the findings of phase 3 clinical trial of plant-based COVID-19 vaccine

Study: Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine. Image Credit: dewa hartawan/Shutterstock

A recent article in the New England Journal of Medicine has presented the safety and efficacy profiles of a plant-based adjuvanted coronavirus disease 2019 (COVID-19) vaccine in human participants. Study: Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine. Image Credit: dewa hartawan/Shutterstock The vaccine includes plant-derived coronavirus-like particles displaying the prefusion-stabilized, full-length spike … Read more

Whom Did COVID Vaccines Protect?

Whom Did COVID Vaccines Protect?

This transcript has been edited for clarity. Welcome to ImpactFactor, your weekly dose of commentary on a new medical study. I’m Dr. F. Perry Wilson of the Yale School of Medicine. Someday, perhaps in the not-too-distant future, we will be able to have a calm and informed debate about what interventions saved the most lives … Read more

Researchers reveal the mechanism of action of century-old BCG vaccine

Booster doses provide strong protection against hospitalization and death from COVID-19

The century-old Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the world’s oldest and most widely used vaccines, used to immunize 100 million newborns every year. Given in countries with endemic TB, it has surprisingly been found to protect newborns and young infants against multiple bacterial and viral infections unrelated to TB. There’s even … Read more