Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model. Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon/Shutterstock Background Due to … Read more

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Study: Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals. Image Credit: Naeblys/Shutterstock

In a recent article posted to the bioRxiv* preprint server, researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals Study: Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals. Image Credit: Naeblys/Shutterstock Background The CoV disease 2019 (COVID-19) catastrophe, which … Read more

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Study: Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron. ​​​​​​​Image Credit: Orpheus FX / Shutterstock

In a recent study published in the journal Vaccinesresearchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron escapes neutralizing antibodies (nAbs). Two days after it was first reported on November 24, 2021, the World Health Organization (WHO) designated SARS-CoV-2 Omicron as a variant of concern (VOC). The WHO estimated a potentially higher risk of … Read more

Study investigates antibody-mediated response against different SARS-CoV-2 variants

Study: SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity. Image Credit: NIAID

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of coronavirus disease 2019 (COVID-19) on antibody-mediated immunity. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been widely reported in individuals with a history of COVID-19 vaccination or infection with a preceding variant. This indicates that immunological heterogeneity exists against … Read more

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers reported that nanoparticles could prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cell entry. Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon/Shutterstock SARS-CoV-2, the causal pathogen of coronavirus disease 2019 (COVID-19), enters human cells by interacting through its spike (S) protein … Read more

Study uncovers new regulator of prostate cancer metastasis

Study uncovers new regulator of prostate cancer metastasis

A transcription factor normally associated with androgen receptor activity in prostate cancer has a newly discovered role in controlling lipid biosynthesis, according to a Northwestern Medicine study published in Nature Genetics. The transcription factor, called HOXB13, is downregulated in late-stage prostate cancer, unleashing lipid biosynthesis and fueling cancer metastasis, according to Jindan Yu, MD, PhD, … Read more

Study reveals immune responses to SARS-CoV-2 peptides in convalescent COVID-19 patients

Study: Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients. Image Credit: Corona Borealis Studio/Shutterstock

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as a “pneumonia of unknown etiology” in Wuhan, China in 2019. The disease caused by SARS-CoV-2 was termed coronavirus disease 2019 (COVID-19) and was declared a pandemic by the World Health Organization (WHO). COVID-19 infections can range from asymptomatic to severe which can ultimately lead to the death … Read more

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities . Please can you introduce yourself, tell us about your background in oncology, and what inspired … Read more

Scientists explore immunopathology of COVID-19

Study: Immunouniverse of SARS-CoV-2. Image Credit: CROCOTHERY/Shutterstock

In a recent review published in Immunological Medicineresearchers explored the interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the host in the development of coronavirus disease 2019 (COVID-19). Study: Immunouniverse of SARS-CoV-2. Image Credit: CROCOTHERY/Shutterstock Background COVID-19 is characterized by a hyperinflammatory and hypercoagulable state, which leads to pneumonia and severe acute respiratory … Read more

Marine bioactive compounds against SARS-CoV-2

Review: Multifaceted role of natural sources for COVID-19 pandemic as marine drugs. Image Credit: Charlotte Bleijenberg / Shutterstock

In the current era, viruses pose a significant threat to humans since they are capable of causing pandemics throughout the world. Changing environments, globalization, urbanization, population growth, and changes in transport and infrastructure have created new opportunities for viral infections to start and spread. Review: Multifaceted role of natural sources for COVID-19 pandemic as marine … Read more