Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

A WEHI-led study has identified a new enzyme involved in controlling cell death, in findings that could lead to better treatment options for a range of inflammatory conditions, cancers and viruses. The discovery offers another way to regulate the cell death process for inflammatory diseases like psoriasis – conditions that occur due to excessive cell … Read more

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Study: Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron. ​​​​​​​Image Credit: Orpheus FX / Shutterstock

In a recent study published in the journal Vaccinesresearchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron escapes neutralizing antibodies (nAbs). Two days after it was first reported on November 24, 2021, the World Health Organization (WHO) designated SARS-CoV-2 Omicron as a variant of concern (VOC). The WHO estimated a potentially higher risk of … Read more

A hybrid, multiscale, individual-based model to study the within-host spread of SARS-CoV-2 and the subsequent innate immune response

Study: Modelling the within-host spread of SARS-CoV-2 infection, and the subsequent immune response, using a hybrid, multiscale, individual-based model. Part I: Macrophages. Image Credit: MedMoMedia/Shutterstock

Scientists have observed that every individual responds differently to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causal agent of the coronavirus disease 2019 (COVID-19) pandemic. The evolution of SARS-CoV-2 due to genomic mutations has resulted in several variants, and each variant manifests the disease differently. Some variants cause severe infection, whereas others cause … Read more

NIH launches clinical study to evaluate an investigational preventative vaccine for Epstein-Barr virus

Booster doses provide strong protection against hospitalization and death from COVID-19

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched an early-stage clinical trial to evaluate an investigational preventative vaccine for Epstein-Barr virus (EBV). EBV is the primary cause of infectious mononucleosis and is associated with certain cancers and autoimmune diseases. The Phase 1 study, which will … Read more

Scientists explore immunopathology of COVID-19

Study: Immunouniverse of SARS-CoV-2. Image Credit: CROCOTHERY/Shutterstock

In a recent review published in Immunological Medicineresearchers explored the interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the host in the development of coronavirus disease 2019 (COVID-19). Study: Immunouniverse of SARS-CoV-2. Image Credit: CROCOTHERY/Shutterstock Background COVID-19 is characterized by a hyperinflammatory and hypercoagulable state, which leads to pneumonia and severe acute respiratory … Read more

Marine bioactive compounds against SARS-CoV-2

Review: Multifaceted role of natural sources for COVID-19 pandemic as marine drugs. Image Credit: Charlotte Bleijenberg / Shutterstock

In the current era, viruses pose a significant threat to humans since they are capable of causing pandemics throughout the world. Changing environments, globalization, urbanization, population growth, and changes in transport and infrastructure have created new opportunities for viral infections to start and spread. Review: Multifaceted role of natural sources for COVID-19 pandemic as marine … Read more

Evaluating the findings of phase 3 clinical trial of plant-based COVID-19 vaccine

Study: Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine. Image Credit: dewa hartawan/Shutterstock

A recent article in the New England Journal of Medicine has presented the safety and efficacy profiles of a plant-based adjuvanted coronavirus disease 2019 (COVID-19) vaccine in human participants. Study: Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine. Image Credit: dewa hartawan/Shutterstock The vaccine includes plant-derived coronavirus-like particles displaying the prefusion-stabilized, full-length spike … Read more

Injectable hydrogels for single-dose COVID-19 vaccination

Study: Injectable Slow-Release Hydrogel Formulation of a Plant Virus-Based COVID-19 Vaccine Candidate. Image Credit: New Africa / Shutterstock

Several coronavirus disease 2019 (COVID-19) vaccines require multiple doses for long-lasting immunity. However, a new study published in the journal Biomacromolecules has developed a promising single-dose vaccine platform using an injectable hydrogel containing an epitope-labeled plant virus, Cowpea mosaic virus (CPMV). Study: Injectable Slow-Release Hydrogel Formulation of a Plant Virus-Based COVID-19 Vaccine Candidatee. Image Credit: … Read more

Longitudinal and proteome-wide analysis of antibodies in COVID-19 patients using a SARS-CoV-2 proteome microarray

Study: Longitudinal and proteome-wide analyses of antibodies in COVID-19 patients reveal features of the humoral immune response to SARS-CoV-2. Image Credit: ker_vii/Shutterstock

The first longitudinal proteome-wide analysis of antibodies in coronavirus disease 2019 (COVID-19) patients has been performed by researchers from the Beijing Institute of Microbiology and Epidemiology and published in the Journal of Advanced Research. Study: Longitudinal and proteome-wide analyzes of antibodies in COVID-19 patients reveal features of the humoral immune response to SARS-CoV-2. Image Credit: … Read more

How do mosquito bites affect immunity?

Study: First-in-human evaluation of cutaneous innate and adaptive immunomodulation by mosquito bites. Image Credit: nechaevkon/Shutterstock

Mosquitoes have been a bane to human health for centuries, with different species carrying the pathogens causing malaria, filaria, dengue and other debilitating or even potentially deadly diseases. A new preprint study looks at the immunomodulatory effects of mosquito bites, using Aedes aegypti as the model species and humans as the host. Study: First-in-human evaluation … Read more