Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model. Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon/Shutterstock Background Due to … Read more

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Study: Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals. Image Credit: Naeblys/Shutterstock

In a recent article posted to the bioRxiv* preprint server, researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals Study: Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals. Image Credit: Naeblys/Shutterstock Background The CoV disease 2019 (COVID-19) catastrophe, which … Read more

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

A WEHI-led study has identified a new enzyme involved in controlling cell death, in findings that could lead to better treatment options for a range of inflammatory conditions, cancers and viruses. The discovery offers another way to regulate the cell death process for inflammatory diseases like psoriasis – conditions that occur due to excessive cell … Read more

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

Study: Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection. Image Credit: NIAID

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection. Various studies have reported novel SARS-CoV-2 mutations that have been associated with increased transmissibility, increased binding to angiotensin-converting enzyme 2 (ACE2), and antibody evasion. However, the functional … Read more

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Study: Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron. ​​​​​​​Image Credit: Orpheus FX / Shutterstock

In a recent study published in the journal Vaccinesresearchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron escapes neutralizing antibodies (nAbs). Two days after it was first reported on November 24, 2021, the World Health Organization (WHO) designated SARS-CoV-2 Omicron as a variant of concern (VOC). The WHO estimated a potentially higher risk of … Read more

Study investigates antibody-mediated response against different SARS-CoV-2 variants

Study: SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity. Image Credit: NIAID

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of coronavirus disease 2019 (COVID-19) on antibody-mediated immunity. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been widely reported in individuals with a history of COVID-19 vaccination or infection with a preceding variant. This indicates that immunological heterogeneity exists against … Read more

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers reported that nanoparticles could prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cell entry. Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon/Shutterstock SARS-CoV-2, the causal pathogen of coronavirus disease 2019 (COVID-19), enters human cells by interacting through its spike (S) protein … Read more

Infection with SARS-CoV-2 results in antibodies against common colds

Researchers analyzed the structures of antibodies (colored) from healthy donors as the molecules bound to the spike protein from common coronaviruses like OC43 (shown here in white/gray). Image Scripps Research

Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides immunity against seasonal human coronaviruses (HCoVs). Whether SARS-CoV-2 infection causes a boost in the preexisting HCoV-specific antibodies or elicits cross-reactive β-CoV antibodies that target conserved epitopes is unknown. A study published in the journal Science Advances uses electron microscopy-based polyclonal epitope mapping (EMPEM) methodology … Read more

Marine bioactive compounds against SARS-CoV-2

Review: Multifaceted role of natural sources for COVID-19 pandemic as marine drugs. Image Credit: Charlotte Bleijenberg / Shutterstock

In the current era, viruses pose a significant threat to humans since they are capable of causing pandemics throughout the world. Changing environments, globalization, urbanization, population growth, and changes in transport and infrastructure have created new opportunities for viral infections to start and spread. Review: Multifaceted role of natural sources for COVID-19 pandemic as marine … Read more

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

Study provides new understanding of how memory works when the brain sees a familiar face

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease, and a study led by the University of California San Diego provides new evidence to support this claim. In analyzing brain tissue, researchers observed a trend consistent with their previous findings in blood … Read more