Important methodology for targeting conserved epitopes of SARS-CoV-2 and an immune-focused approach in pan-sarbeco and universal CoV vaccine design

Study: Adaptation-proof SARS-CoV-2 vaccine design. Image Credit: creativeneko/Shutterstock

The ongoing coronavirus disease 2019 (COVID-19), whose causative agent is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has massively affected the global economy and healthcare system. Although scientists have rapidly developed effective COVID-19 vaccines, their efficacy has reduced owing to the emergence of new SARS-CoV-2 variants that can evade immune responses generated via vaccination or … Read more

COVID-19’s impact on sex and fertility

Study: How has COVID-19 affected sex and fertility? Image Credit: Chinnapong / Shutterstock.com

The pathophysiology of the coronavirus disease 2019 (COVID-19) is associated with a wide range of functional changes in several physiological parameters. The direct impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male and female urogenital organs has yet to be determined. Nevertheless, various explanations have been offered based on biological similarities between … Read more

Natural immunity weak and short-lived in unvaccinated after Omicron infection

Study: Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Image Credit: Naeblys / Shutterstock

In a recent study posted to the journal Natureresearchers showed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infection without SARS-CoV-2 vaccination conferred poor cross-variant neutralizing capacities. Study: Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Image Credit: Naeblys/Shutterstock Background Numerous waves of infection have occurred since the start of the CoV disease … Read more

SARS-CoV-2 Omicron linked to rise in croup in young children

Study: COVID-19–Associated Croup in Children. Image Credit: VGstockstudio / Shutterstock.com

A recent Pediatrics study assesses the causative relationship between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and croup or “barking cough” in children. Study: COVID-19–Associated Croup in Children. Image Credit: VGstockstudio / Shutterstock.com Coronaviruses and croup Throughout the entire duration of the coronavirus disease 2019 (COVID-19) pandemic, the causative SARS-CoV-2 has evolved. The … Read more

Incidence of arterial and venous thromboembolism and death in COVID-19 patients

Study: Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study. Image Credit: MattLphotography/Shutterstock

In a recent study published in Infectious Diseasesresearchers estimated the incidence of arterial or venous thrombosis in patients with coronavirus disease 2019 (COVID-19). Study: Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study. Image Credit: MattLphotography/Shutterstock Background COVID-19 could cause arterial/venous thromboembolism due to inflammation, activation of platelets, endothelial dysfunction, … Read more

COVID-19 mortality strongly predicted by autoimmunity to type I interferons and advancing age

Study: The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies. Image Credit: NIAID

In a recent study published in the journal PNAS, researchers estimated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) and relative risk of death (RRD) among subjects across ages. Study participants were either carriers of autoantibodies (auto-Abs) which neutralized low concentrations (100 pg/mL), or high concentrations (10 ng/mL) of type I … Read more

How does diet affect COVID-19?

Study: Do Diet and Dietary Supplements Mitigate Clinical Outcomes in COVID-19? Image Credit: New Africa / Shutterstock.com

The coronavirus disease 2019 (COVID-19) is a respiratory disease with a strong inflammatory component known as the cytokine storm that often occurs in individuals with severe disease. While many researchers are currently investigating treatments to prevent the cytokine storm, variations in diet can also significantly alter the risk of inflammation. In a recent Nutrients study, … Read more

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model. Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon/Shutterstock Background Due to … Read more

Study explores lipid nanoparticles against SARS-CoV-2

Study: Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant. Image Credit: Crevis/Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers assessed the efficiency of lipid nanoparticles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant. Image Credit: Crevis/Shutterstock Messenger ribonucleic acid (mRNA) vaccines have played an instrumental role in curbing coronavirus disease … Read more

Evaluating SARS-CoV-2 infection risk in indoor environments

Study: Transmissibility of coronavirus and its variants from infected subjects in indoor environments. Image Credit: Elizaveta Galitckaia / Shutterstock

In a recent study under review at the Scientific Reports journal and posted to the Research Square* preprint server, researchers evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection risk for indoor scenarios. Study: Transmissibility of coronavirus and its variants from infected subjects in indoor environments. Image Credit: Elizaveta Galitckaia / Shutterstock Background Apart from … Read more