New study helps to better understand re-infection rates and correlates of protection for SARS-CoV-2

New compound delivered in a nasal spray effectively treats delta variant infection in mice

By uniting research from 8 cohorts across the US, a group of researchers has accelerated collection of integral data in answering questions about immune responses needed for long lasting protection from SARS-CoV-2. The description of the cohorts, the assays used and the definitions for events were reported recently in the journal mSpherean open access journal … Read more

Study explores lipid nanoparticles against SARS-CoV-2

Study: Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant. Image Credit: Crevis/Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers assessed the efficiency of lipid nanoparticles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant. Image Credit: Crevis/Shutterstock Messenger ribonucleic acid (mRNA) vaccines have played an instrumental role in curbing coronavirus disease … Read more

Exploring short-term effectiveness of COVID-19 booster vaccine and stable CD8+ T cell memory after three doses

Study: Short-lived booster effect and stable CD8+ T cell memory after 3rd COVID-19 vaccine dose. Image Credit: KT Stock photos/Shutterstock

Since the initial global outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, a continuous evolution of the virus has been observed. The emergence of new SARS-CoV-2 variants, which have been classified as variants of concern (VOC) and variants of interest (VOI), has reduced the efficacy … Read more

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

A WEHI-led study has identified a new enzyme involved in controlling cell death, in findings that could lead to better treatment options for a range of inflammatory conditions, cancers and viruses. The discovery offers another way to regulate the cell death process for inflammatory diseases like psoriasis – conditions that occur due to excessive cell … Read more

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

Study: Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection. Image Credit: NIAID

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection. Various studies have reported novel SARS-CoV-2 mutations that have been associated with increased transmissibility, increased binding to angiotensin-converting enzyme 2 (ACE2), and antibody evasion. However, the functional … Read more

Messenger RNA COVID-19 vaccines induce high levels of short-lived antibodies compared to natural infection

Study: High but Short-lived anti-SARS-CoV2 neutralizing, IgM, IgA, and IgG levels among mRNA-vaccinees compared to naturally-infected participants. Image Credit: PIC SNIPE/Shutterstock

In a recent study posted to the medRxiv* pre-print server, researchers extensively investigated the dynamics of antibodies induced by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination in Qatar’s diverse population. The researchers found that the two-dose vaccine regimen with a messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine boosted antibody … Read more

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Study: Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron. ​​​​​​​Image Credit: Orpheus FX / Shutterstock

In a recent study published in the journal Vaccinesresearchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron escapes neutralizing antibodies (nAbs). Two days after it was first reported on November 24, 2021, the World Health Organization (WHO) designated SARS-CoV-2 Omicron as a variant of concern (VOC). The WHO estimated a potentially higher risk of … Read more

Study investigates antibody-mediated response against different SARS-CoV-2 variants

Study: SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity. Image Credit: NIAID

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of coronavirus disease 2019 (COVID-19) on antibody-mediated immunity. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been widely reported in individuals with a history of COVID-19 vaccination or infection with a preceding variant. This indicates that immunological heterogeneity exists against … Read more

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers reported that nanoparticles could prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cell entry. Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon/Shutterstock SARS-CoV-2, the causal pathogen of coronavirus disease 2019 (COVID-19), enters human cells by interacting through its spike (S) protein … Read more

Study reveals immune responses to SARS-CoV-2 peptides in convalescent COVID-19 patients

Study: Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients. Image Credit: Corona Borealis Studio/Shutterstock

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as a “pneumonia of unknown etiology” in Wuhan, China in 2019. The disease caused by SARS-CoV-2 was termed coronavirus disease 2019 (COVID-19) and was declared a pandemic by the World Health Organization (WHO). COVID-19 infections can range from asymptomatic to severe which can ultimately lead to the death … Read more