Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model. Study: A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection. Image Credit: Kateryna Kon/Shutterstock Background Due to … Read more

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Study: Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals. Image Credit: Naeblys/Shutterstock

In a recent article posted to the bioRxiv* preprint server, researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals Study: Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals. Image Credit: Naeblys/Shutterstock Background The CoV disease 2019 (COVID-19) catastrophe, which … Read more

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

Study: Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection. Image Credit: NIAID

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection. Various studies have reported novel SARS-CoV-2 mutations that have been associated with increased transmissibility, increased binding to angiotensin-converting enzyme 2 (ACE2), and antibody evasion. However, the functional … Read more

SARS-CoV-2 Omicron escapes immune response due to high ACE2 affinity and low antibody specificity

Study: Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron. ​​​​​​​Image Credit: Orpheus FX / Shutterstock

In a recent study published in the journal Vaccinesresearchers revealed how severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron escapes neutralizing antibodies (nAbs). Two days after it was first reported on November 24, 2021, the World Health Organization (WHO) designated SARS-CoV-2 Omicron as a variant of concern (VOC). The WHO estimated a potentially higher risk of … Read more

Decoy ACE2 nanoparticles block the entry of SARS-CoV-2 into cells

Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon / Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers reported that nanoparticles could prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cell entry. Study: ACE2 nanoparticles prevent cell entry of SARS-CoV-2. Image Credit: Kateryna Kon/Shutterstock SARS-CoV-2, the causal pathogen of coronavirus disease 2019 (COVID-19), enters human cells by interacting through its spike (S) protein … Read more

Scientists explore immunopathology of COVID-19

Study: Immunouniverse of SARS-CoV-2. Image Credit: CROCOTHERY/Shutterstock

In a recent review published in Immunological Medicineresearchers explored the interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the host in the development of coronavirus disease 2019 (COVID-19). Study: Immunouniverse of SARS-CoV-2. Image Credit: CROCOTHERY/Shutterstock Background COVID-19 is characterized by a hyperinflammatory and hypercoagulable state, which leads to pneumonia and severe acute respiratory … Read more

Marine bioactive compounds against SARS-CoV-2

Review: Multifaceted role of natural sources for COVID-19 pandemic as marine drugs. Image Credit: Charlotte Bleijenberg / Shutterstock

In the current era, viruses pose a significant threat to humans since they are capable of causing pandemics throughout the world. Changing environments, globalization, urbanization, population growth, and changes in transport and infrastructure have created new opportunities for viral infections to start and spread. Review: Multifaceted role of natural sources for COVID-19 pandemic as marine … Read more

Precision cut slice lung model to study early host viral pathogenesis of SARS-CoV-2 infection

Study: Immediate myeloid depot for SARS-CoV-2 in the human lung. Image Credit: Cinefootage Visuals/Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers applied their previously developed precision-cut lung slice (PCLS) model to study the initial events in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenicity in humans. Study: Immediate myeloid depot for SARS-CoV-2 in the human lung. Image Credit: Cinefootage Visuals/Shutterstock SARS-CoV-2 infects and replicates in … Read more

Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19

Study: Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. Image Credit: Alpha Tauri 3D Graphics/Shutterstock

In a recent study published in Signal Transduction and Target Therapy, researchers reviewed the potential clinically relevant mechanisms by which microbiota and microbiota-derived metabolites influence the host immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Additionally, they explored several microbiota-based therapeutic and prophylactic interventions for coronavirus disease 2019 (COVID-19) and post-acute COVID-19 … Read more

The generation of SARS-CoV-2 virus-like particles in insect cells

Study: SARS-CoV-2 Virus-like Particles Produced by a Single Recombinant Baculovirus Generate Anti-S Antibody and Protect against Variant Challenge. Image Credit: creativeneko/Shutterstock

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in the COVID-19 pandemic, has pushed the world towards developing rushed but effective vaccines against the disease. Most currently employed COVID-19 vaccines rely on the principle of virus inactivation, adenoviral vectors, or the use of direct nucleic acids (mRNA/DNA). Study: SARS-CoV-2 Virus-like Particles … Read more